Monochrome malady takes place in Mississippi in the year of 1985.Its a story about a man named Austine Jose. He is a man with a very tragic backstory. He applied to a mental hospital called Camila Rodrigo Mental Hospital. He got applied by the head of psychiatric department named Nick Rodrigo. After that Nick introduced one of the patients named Sylvia. The story is focused on the romantic situation between Austine and Sylvia.